CAPTURE - Combating Pseudomonas aeruginosa infections with antimicrobial peptide carriers
Abstract
Pseudomonas aeruginosa is a major cause of antibiotic-resistant hospital-acquired infections, including ventilator-associated pneumonia and sepsis. This pathogen exacerbates the condition of already compromised patients and poses a significant challenge in healthcare settings. Our project, CAPTURE, tackles this challenge by proposing a novel approach using specialized transport vesicles, such as lipid-based nanocarriers and outer membrane vesicles, to deliver plasmids encoding potent antimicrobial peptides (AMPs) directly into bacterial cells. By delivering our plasmid, we aim to create a targeted therapeutic system for eradicating P. aeruginosa infections. Focusing on lung infections, we plan to administer the carriers using an aerosol delivery system. This innovative strategy combines synthetic biology and drug delivery techniques to enhance AMP efficacy. Our research has the potential to develop a novel therapeutic approach that could reduce the mortality rates associated with P. aeruginosa in hospitals.
Wiki
https://2024.igem.wiki/freiburg/
Achievements
- Top 10 Overgraduate
- Gold Medal
- Best Infectious Disease Project
- Best Integrated Human Practices, Overgrad - Nomination
- Best New Composite Part, Overgrad - Nomination
- Best Measurement, Overgrad - Nomination
- Best Presentation, Overgrad - Nomination
- Best Wiki, Overgrad - Nomination
Meet The Team
Picture: iGEM Foundation
Primary PI
- Dr. Nicole Gensch
- Dr. Pavel Salavei
Student Members
- Alexej Wolosski
- Emil Kozma
- Isabelle Tipp
- Ivana Rozić
- Jan Zielinski
- Laura Pasman
- Leonie Mungenast
- Liv Neumann
- Lucille Gutzmer
- Marina Hammerl
- Mathilda Bertges
- Nafis Madappalli
- Nicole Kucera
- Niels Geipel
Instructors
Advisors
- Amelie Stange
- Anna Indricane
- Kevin Postol
- Konstantin Jäschke
- Yara Jenin Jamal
- Hannah Swientek